Bipolar Disorder

What is Bipolar Disorder?

Bipolar disorder is a serious mood disorder marked by episodes of mania or hypomania (extreme highs) and depression (extreme lows). These mood shifts can last days, weeks, or even months and significantly impact daily functioning, relationships, and overall quality of life. Unlike typical mood fluctuations, the intensity and duration of these episodes distinguish bipolar disorder.

According to the National Institute of Mental Health, about 2.8% of adults in the United States experience bipolar disorder in a given year, with many living with the condition for decades. While there is no cure, bipolar disorder is treatable through a combination of medication, psychotherapy, and lifestyle management. Early diagnosis and personalized care are crucial to managing symptoms and improving outcomes.

Table of Contents

  • What Is Bipolar Disorder?

  • Types of Bipolar Disorder

  • Symptoms of Bipolar Disorder

  • Possible Causes and Risk Factors

  • Everyday Triggers and Environmental Factors

  • Biological and Genetic Factors

  • Approaches to Managing and Treating Bipolar Disorder

  • Bipolar Disorder Across the Lifespan: Children, Teens, and Older Adults

  • When to Seek Help

  • Telehealth and Digital Support for Bipolar Disorder

  • References

Types of Bipolar Disorder

Each type of bipolar disorder has a unique set of features and a distinct lifetime risk:

  • Bipolar I Disorder [Lifetime risk: ~0.6-1.8%]
     Characterized by at least one episode of mania (lasting at least seven days or requiring hospitalization). Major depressive episodes are common but not needed for diagnosis.

  • Bipolar II Disorder [Lifetime risk: ~1.1-1.7%]
     Involves at least one major depressive episode and one hypomanic episode (less severe than full mania). Full manic episodes do not occur.

  • Cyclothymic Disorder (Cyclothymia) [Lifetime risk: ~0.5–1.0%]
     Consists of numerous periods of hypomanic and depressive symptoms that do not fully meet criteria for a hypomanic or depressive episode.

  • Other Specified and Unspecified Bipolar and Related Disorders [Lifetime risk: included within the broader spectrum, rare individually]
     These diagnoses capture bipolar symptoms that do not fit into the categories above but still involve significant mood cycling.

Symptoms of Bipolar Disorder

Manic or Hypomanic Episode

  • Increased energy, activity, or restlessness

  • Extremely elevated or irritable mood

  • Decreased need for sleep

  • Talking more than usual; pressured speech

  • Racing thoughts or distractibility

  • Inflated self-esteem or grandiosity

  • Engaging in risky behaviors (overspending, unsafe activity)

Depressive Episode

  • Persistent sadness or low mood

  • Loss of interest in activities

  • Changes in appetite or weight

  • Trouble sleeping or excessive sleep

  • Fatigue or low energy

  • Difficulty concentrating

  • Feelings of worthlessness or guilt

  • Thoughts of death or suicide

Possible Causes and Risk Factors

Bipolar disorder arises from a complex interplay of genetic, biological, and environmental factors. Having a first-degree relative with bipolar disorder significantly increases risk. Neurochemical imbalances and altered brain structure also contribute.

Everyday Triggers and Environmental Factors

Life stressors, such as relationship problems, job changes, sudden life events, and substance use, can trigger or worsen mood episodes. Disrupted sleep and inconsistent routines often make symptoms more severe.

Biological and Genetic Factors

Bipolar disorder frequently runs in families, supporting a strong genetic component. Twin and family studies support higher risks in first-degree relatives. Neuroimaging shows differences in emotion-regulating brain areas, and neurotransmitters such as serotonin, dopamine, and norepinephrine are often implicated.

Approaches to Managing and Treating Bipolar Disorder

  • Medication: Mood stabilizers (such as lithium), antipsychotics, and sometimes antidepressants are mainstays of treatment.

  • Psychotherapy: Includes cognitive-behavioral therapy (CBT), family-focused therapy, and psychoeducation.

  • Lifestyle Management: Maintaining regular routines, stable sleep schedules, healthy eating, and physical activity support long-term stability.

  • Support Networks: Involvement of family, support groups, and peers contributes to positive outcomes.

  • Crisis Planning: Emergency plans are essential for episodes of severe mood change or suicidal risk.

When Standard Treatments Don’t Work

Approximately 25–33% of patients with bipolar disorder experience treatment-resistant bipolar depression (TRBD), where depressive symptoms persist despite adequate medication trials. Treatment resistance is also seen in manic phases. Challenges include mixed features, cognitive dysfunction, and comorbidities.

Emerging treatment strategies include:

  • Augmentation with pramipexole, modafinil, or ketamine (limited short-term evidence)

  • Electroconvulsive therapy (ECT), especially unilateral ECT

  • Investigational neuromodulation therapies like transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), and deep brain stimulation (DBS)

  • New pharmacological agents under study (e.g., brexpiprazole, vortioxetine)

  • Innovative research into psychedelic-assisted psychotherapy and other novel approaches

Medication and Other Medical Interventions

Mood stabilizers (lithium being the gold standard), anticonvulsants, atypical antipsychotics, and selective antidepressants (used cautiously) form the pharmacological basis.

Bipolar Disorder Across the Lifespan: Children, Teens, and Older Adults

Symptoms and management may differ by age group. Early-onset bipolar disorder often has more severe courses, and tailored approaches for youth and elderly populations are important.

When to Seek Help

If you or someone you know experiences ongoing mood swings disrupting daily life, consult a mental health professional. Early treatment can help manage symptoms and improve quality of life.

Telehealth and Digital Support for Bipolar Disorder

Telehealth enables access to mental health professionals through video, phone, or messaging, providing flexibility and continuity of care. Digital symptom-tracking apps can help with self-management between visits

Benefits of Telehealth

  • Convenience: Attend sessions from your home, saving time and travel.

  • Accessibility: Get care even if you live in a rural area or have a busy schedule.

  • Comfort: Many people feel more at ease talking about their worries in a familiar setting.

Effectiveness: Studies show that telehealth is just as effective as in-person therapy for treating disorders.

References

  1. American Psychiatric Association - APA (2002). Practice Guideline for the treatment of patients with bipolar disorder. 2nd edition. Arlington: APPI.

  2. Clemente, A. S., Diniz, B. S., Nicolato, R., Kapczinski, F. P., Soares, J. C., Firmo, J. O., & Castro-Costa, É. (2015). Bipolar disorder prevalence: a systematic review and meta-analysis of the literature. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 37(2), 155–161. https://doi.org/10.1590/1516-4446-2012-1693

  3. Healthline. (2025, January 3). What’s the Life Expectancy with Bipolar Disorder? https://www.healthline.com/health/bipolar-disorder/life-expectancy-with-bipolar-disorder

  4. Grande, I., Berk, M., Birmaher, B., & Vieta, E. (2016). Bipolar disorder. The Lancet, 387(10027), 1561–1572. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00241-X/abstract

  5. MedCentral. (n.d.). Prevalence of Bipolar 1 Disorder. https://www.medcentral.com/behavioral-mental/bipolar-disorder/bipolar-disorder-prevalence-and-risks

  6. Merikangas, K. R., Akiskal, H. S., Angst, J., Greenberg, P. E., Hirschfeld, R. M., Petukhova, M., & Kessler, R. C. (2007). Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Archives of general psychiatry, 64(5), 543–552. https://doi.org/10.1001/archpsyc.64.5.543

  7. Merikangas, K. R., Jin, R., He, J. P., Kessler, R. C., Lee, S., Sampson, N. A., et al. (2011). Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Archives of General Psychiatry, 68(3), 241–251.

  8. Rowland, T. A., & Marwaha, S. (2018). Epidemiology and risk factors for bipolar disorder. Therapeutic advances in psychopharmacology, 8(9), 251–269. https://doi.org/10.1177/2045125318769235

  9. Steventon, A., Bardsley, M., Billings, J., Dixon, J., Doll, H., Hirani, S., et al. (2012). Effect of telehealth on use of secondary care and mortality: Findings from the Whole System Demonstrator cluster randomised trial. BMJ, 344, e3874. https://doi.org/10.1136/bmj.e3874